Reflux-related disorders, including GERD (Gastroesophageal Reflux Disease) and LPRD (Laryngopharyngeal Reflux Disease), are characterized by impairment of the esophageal mucosal barrier, often caused by prolonged exposure to gastric acid.

Although pharmacological treatments such as proton pump inhibitors (PPIs) remain the standard of care, a significant proportion of patients do not achieve adequate symptom control. In this context, increasing attention is being given to complementary approaches based on mechanical mucosal protection.

The role of alginates and natural polysaccharides

Alginates are widely used due to their ability to:

• form a physical “raft” that limits reflux

• adhere to the mucosa, creating a protective layer

• support tissue repair processes

At the same time, plant-derived polysaccharides are known for their:

• mucoadhesive properties

• soothing and protective effects

• potential anti-inflammatory activity

Combining these components represents an innovative strategy in the development of medical devices for reflux management.

The Complife study: model and objectives

The in vitro study was conducted using a reconstructed human esophageal epithelium model, enabling a physiologically relevant simulation of in vivo conditions.

The main objective was to evaluate the mucoadhesive capacity of an innovative formulation containing:

• magnesium alginate

• natural polysaccharides (from Opuntia ficus-indica and Olea europaea)

and to compare it with:

• hyaluronic acid (benchmark)

• commercially available formulations

Key findings

The results clearly show that:

• The tested formulation exhibited higher mucoadhesive capacity compared to hyaluronic acid as early as 30 minutes

• This superiority was maintained and increased over time (up to 4 hours)

• Compared to marketed products, the formulation demonstrated significantly stronger adhesion at all time points

These findings are likely explained by:

• synergistic interactions between alginates and polysaccharides

• greater structural stability (not susceptible to enzymatic degradation)

• higher viscosity, enhancing residence time on the mucosa

Practical implications

These results support the hypothesis that combining alginates with natural polysaccharides may:

• enhance esophageal mucosal protection

• prolong barrier effect

• support physiological repair processes

This approach opens new perspectives for the development of effective medical devices in reflux management.

Conclusions

Mucoadhesion is emerging as a key strategy in the management of reflux-related disorders, particularly as a complementary approach to conventional therapies.

The evidence generated confirms the value of innovative formulations capable of combining efficacy, safety, and prolonged action.

Download the full PDF of the study to explore all results in detail.

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