A food supplement formulated with grape seed extract, grape pomace extract, and licorice root extract (patent pending WO2022/069416), has shown promising depigmenting activity, including inhibition of tyrosinase, the key enzyme in melanogenesis. While its efficacy has been demonstrated in Asian populations, this study aimed to evaluate its potential in a Caucasian cohort with Fitzpatrick skin types I to III, who are more prone to visible hyperpigmentation.

A multicentric, randomized, double-blind, placebo-controlled clinical study was conducted by our team of experts to evaluate the efficacy and safety of a food supplement in adult Caucasian subjects with facial hyperpigmentation. Sixty-six participants (aged 28–52) were enrolled and randomized to receive two capsules per day (300 mg or maltodextrin placebo) for 12 weeks.

Our study protocol included:
– Standardized digital imaging (Visia-CR with RBX brown filter) and spectrophotometric assessment of facial dark spots and erythema;
– MED (Minimal Erythema Dose) UVB exposure tests;
– Clinical evaluations of skin brightness and complexion evenness;
– Monitoring of compliance, tolerability, and adverse events (AEs/SAEs);
– Collection of self-assessment questionnaires at the end of treatment.

READ THE COMPLETE STUDY, DOWNLOAD THE PDF.

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