Slimming: When ultrasound waves penetrate a tissue, reflections occur at different tissue boundaries (i.e. fat-muscle and muscle-bone). This technique allows to measure the fat tissue thickness in single precise points as well as to scan a part of the body to track local fat loss. Claims Slimming effect Remodelling effect Other techniques Macrophotography Circumferences; Bioimpedentiometry…
Ecotoxicity: These assays are aimed at evaluating the environment risk hazard of substances, involving a number of different terrestrial and aquatic bioindicators (toxicity to algae Pseudokirchneriella subcapitata – OECD 201, crustacean Daphnia magna – OECD 202, fish Brachidanio rerio – OECD 203) and Biodegradability testing (OECD 301 and 306) Complife Support Line+39 0382 25 504Tests…
Sensitization efficacy is assessed using different techniques: Sensitization tests are useful to assess whether the product in exam may cause adverse effects involving immunological mechanisms; in vitro methods are currently under validation process. The human Cell Line Activation Test (h-CLAT) quantifies the induction of protein markers on the surface of THP-1 cell lines after exposure to…
Skin Irritation and Corrosion: Topical exposure to chemicals can lead to adverse skin effects. Depending on the severity and reversibility of the response it is possible to distinguish between skin corrosion and irritation. Corrosive substances irreversibly damage the skin, while irritant substances lead to a reversible local inflammatory reaction. In vitro test methods, including assays…
Home Use test under ophthalmologist control Home-use test under ophthalmologist control is aimed to assess the tolerability of cosmetic products/suncreens/cosmetotextile products/household products, under real conditions of use. The product is delivered to the subjects for a daily regular use; at fixed experimental times the ophthalmologist evaluates the absence of adverse signs. Claims Tolerance tested Tested…
Home Use test under dermatologist control Home-use test under dermatologist control is aimed to assess the tolerability of cosmetic products/suncreens/cosmetotextile products/household products, under real conditions of use. The product is delivered to the subjects for a daily regular use; at fixed experimental times the dermatologist evaluates the absence of adverse signs. Claims Tolerance tested Tested…
Home use tests: Home use tests are aimed to evaluate the tolerability of products under real conditions of use. The product is supplied to the subjects for a daily regular use. Product tolerability is assessed by a highly skilled specialist at fixed experimental times. Claims Tolerance tested Tested under medical supervision For sensitive skin For…
Human Repeated Insult Patch (HRIPT), Shelansky & Shelansky / Marzulli & Maibach: The Human Repeated Insult Patch Test is aimed to assess the incidence of skin sensitization which may be induced by the test product when repeatedly applied on the skin. The test is carried out on healthy subjects under occlusive/semi-occlusive/open conditions, depending on the…
96 hours Irritation Patch Test: The 96 hours (4×24 or 2×48 hours) patch test is aimed to assess the incidence of cumulative skin irritation signs which may be induced by the test product when applied on the skin up to 96 hours. The test is carried out on healthy subjects under occlusive/semi-occlusive/open conditions, depending on…
Single Application Irritation Patch Test (4h/24h/48h): The single application irritation patch test is aimed to assess the incidence of skin irritation which may be induced by the test product when applied on the skin up to 4 hours, 24 hours or 48 hours, depending on the product typology. The test is carried out on healthy…