Ecotoxicity

Ecotoxicity: These assays are aimed at evaluating the environment risk hazard of substances, involving a number of different terrestrial and aquatic bioindicators (toxicity to algae Pseudokirchneriella subcapitata – OECD 201, crustacean Daphnia magna – OECD 202, fish Brachidanio rerio – OECD 203) and Biodegradability testing (OECD 301 and 306) ServicesAuditingCertificationConsultingInspectionTests and AnalysisChemical AnalysisEfficacy TestsMicrobiological TestsSafety…

Sensitization

Sensitization¬†efficacy is assessed using different techniques: Sensitization tests are useful to assess whether the product in exam may cause adverse effects involving immunological mechanisms; in vitro methods are currently under validation process. The human Cell Line Activation Test (h-CLAT) quantifies the induction of protein markers on the surface of THP-1 cell lines after exposure to…

Skin Irritation and Corrosion

Skin Irritation and Corrosion: Topical exposure to chemicals can lead to adverse skin effects. Depending on the severity and reversibility of the response it is possible to distinguish between skin corrosion and irritation. Corrosive substances irreversibly damage the skin, while irritant substances lead to a reversible local inflammatory reaction. In vitro test methods, including assays…

Home Use test under ophthalmologist control

Home Use test under ophthalmologist control Home-use test under ophthalmologist control is aimed to assess the tolerability of cosmetic products/suncreens/cosmetotextile products/household products, under real conditions of use. The product is delivered to the subjects for a daily regular use; at fixed experimental times the ophthalmologist evaluates the absence of adverse signs. Claims Tolerance tested Tested…

Home Use test under dermatologist control

Home Use test under dermatologist control Home-use test under dermatologist control is aimed to assess the tolerability of cosmetic products/suncreens/cosmetotextile products/household products, under real conditions of use. The product is delivered to the subjects for a daily regular use; at fixed experimental times the dermatologist evaluates the absence of adverse signs. Claims Tolerance tested Tested…

Home use test

Home use tests: Home use tests are aimed to evaluate the tolerability of products under real conditions of use. The product is supplied to the subjects for a daily regular use. Product tolerability is assessed by a highly skilled specialist at fixed experimental times. Claims Tolerance tested Tested under medical supervision For sensitive skin For…

Human Repeated Insult Patch (HRIPT), Shelansky & Shelansky / Marzulli & Maibach

Human Repeated Insult Patch (HRIPT), Shelansky & Shelansky / Marzulli & Maibach: The Human Repeated Insult Patch Test is aimed to assess the incidence of skin sensitization which may be induced by the test product when repeatedly applied on the skin. The test is carried out on healthy subjects under occlusive/semi-occlusive/open conditions, depending on the…

Patch and Controlled Tests

Patch and Controlled Tests: Human patch and controlled testing is a branch of our safety assessment program aimed at evaluating the effects of products coming into contact with the skin: Irritation (skin inflammation resulting in skin redness and swelling) Photo-irritation (skin inflammation resulting in skin redness and swelling after UV exposure) Sensitization (elicitation of an…