Acute Toxicity:
Acute systemic toxicity testing concerns the assessment of the systemic toxic effects of a single dose or multiple doses of a product by a particular route (oral, dermal, inhalation).
BALB 3T3 NRU cytotoxicity in vitro assay is useful to estimate starting doses for acute oral systemic toxicity tests. Officially accepted in vivo tests to predict acute oral toxicity involve Fixed Dose Procedure and Class Method.
