A new study on evaluating the effectiveness of a supplement has been published by COMPLIFE with the title: “Efficacy of Oryza Sativa L. (Black Rice) and Opuntia Ficus Indica L. Blend in Men with Androgenetic Alopecia: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial”.
The article was published in the prestigious (impact factor: 9.9) “Journal of Cosmetology & Trichology.”
Androgenetic Alopecia (AGA) is a progressive hair loss type affecting up to 80% of men and 50% of women. The putative mechanisms in the pathogenesis of AGA include microinflammation, premature cell senescence, oxidative stress, follicle vascular changes and altered sensitivity of hair follicles to androgens.
Our team carried out a randomized, double-blind, placebo-controlled trial on 86 male subjects with AGA from II to III vertex (Hamilton-Norwood).
- Meausure product efficacy after 3, 6 months of product intake and 1-month post-supplementation.
- Assessment of the clinical and self-perceived effects done with subject scoring and dermatological evaluation.
CRITERIA FOR PARTICIPANTS
- The participants are 86 male;
- healthy adults aged between 18 and 55 years old (extremes included) showing mild-to-moderate androgenetic alopecia degree (from II to III vertex on Hamilton-Norwood scale);
Anagen, telogen and hair density were estimated in a target area and automatically calculated by TrichoScan® (Tricholog GmbH & Datinf GmbH, Freiburg, Germany) software;
GLOBAL PHOTOGRAPHY ASSESSMENT
The clinical scoring of hair growth was performed by the dermatologist on standardized pictures, scored using a 7-point scale;
SELF ASSESSMENT QUESTIONNAIRE
Subjects were asked to score the product efficacy;
A two-way t test of Student was performed for normally distributed data (instrumental measurements) while a Wilcoxon or a Mann-Whitney U test was performed for non-parametric data (clinical analysis).
During this 6 mo intervention plus 1 mo follow-up clinical trial, the active was well tolerated by all the subjects participating in the study, with a safety profile comparable to the one of placebo product.
The hair density, the anagen hair and the telogen hair parameters measured by phototricogram were all statistically significantly improved with a positive impact on hair growth. The improvement was supported also by a progressive and visible clinical finding as well as by the self-assessment carried out by the subjects participating in the study.
Subjects in the placebo group did not show any significant improvement of their AGA condition for any parameter measured in the placebo treatment arm.
Read the complete study:
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R&D Cosmetics Market Manager
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