Sensitization efficacy is assessed using different techniques: Sensitization tests are useful to assess whether the product in exam may cause adverse effects involving immunological mechanisms; in vitro methods are currently under validation process. The human Cell Line Activation Test (h-CLAT) quantifies the induction of protein markers on the surface of THP-1 cell lines after exposure to…
Percutaneous and Mucosal Absorption: Percutaneous absorption test measures the diffusion of chemicals into and across skin/epithelium to a fluid reservoir. Such methods are useful to monitor and compare the delivery of chemicals deriving from different formulations into and through skin layers, as well as are reliable models for the assessment of percutaneous absorption in humans.…
Home Use test under dentist control Home Use test under dentist control is aimed to assess the tolerability of products for the oral care, under real conditions of use. The product is delivered to the subjects for a daily regular use; at fixed experimental times the dentist evaluates the absence of adverse signs. Claims Tolerance…
Home Use test under gynaecologist control Home-use test under gynaecologist control is aimed to assess the tolerability of products for the intimate hygiene, under real conditions of use. The product is delivered to the subjects for a daily regular use; at fixed experimental times the gynaecologist evaluates the absence of adverse signs. Claims Tolerance tested…
Home Use test under ophthalmologist control Home-use test under ophthalmologist control is aimed to assess the tolerability of cosmetic products/suncreens/cosmetotextile products/household products, under real conditions of use. The product is delivered to the subjects for a daily regular use; at fixed experimental times the ophthalmologist evaluates the absence of adverse signs. Claims Tolerance tested Tested…
Home Use test under dermatologist control Home-use test under dermatologist control is aimed to assess the tolerability of cosmetic products/suncreens/cosmetotextile products/household products, under real conditions of use. The product is delivered to the subjects for a daily regular use; at fixed experimental times the dermatologist evaluates the absence of adverse signs. Claims Tolerance tested Tested…
Home use tests: Home use tests are aimed to evaluate the tolerability of products under real conditions of use. The product is supplied to the subjects for a daily regular use. Product tolerability is assessed by a highly skilled specialist at fixed experimental times. Claims Tolerance tested Tested under medical supervision For sensitive skin For…
Hand Immersion Test Panelists enrolled in the Hand Immersion Test soak their hands in 2 different hand/dish washing products, once a day for 30 minutes for 5 consecutive days. Products are tested at usual dilution for hand/dishwashing solution and are randomized between the dominant and non-dominant hands of panelists. Skin reactions (redness and dryness) are…
Flex Wash Test: The antecubital fossa of the arm (flex area) is the test skin area for the Flex Wash Test. Two products are generally compared and tested at the same time. This test is helpful to discriminate the mildness or the irritancy of personal cleansing products. All wash treatments are performed under the supervision of…
Comedogenicity Patch test The comedogenicity patch test is aimed to assess the comedogenic potential of the test product when repeatedly applied on comedone/acne-prone skin up to 48 hours per week for 4 consecutive weeks. The test is carried out on healthy subjects under occlusive condition. Skin reactions (comedones proliferation) are assessed by a highly trained…