Reproductive toxicity: A set of in vitro testing for the reproduction risk assessment is performed, basing on assisted reproduction techniques, such as the in vitro oocyte maturation and fecundation assays on bovine model. In vitro maturation test: an assay reproducing the process of oocyte maturation, which corresponds to the pre-ovulatory in vivo phase that allows…
Ecotoxicity: These assays are aimed at evaluating the environment risk hazard of substances, involving a number of different terrestrial and aquatic bioindicators (toxicity to algae Pseudokirchneriella subcapitata – OECD 201, crustacean Daphnia magna – OECD 202, fish Brachidanio rerio – OECD 203) and Biodegradability testing (OECD 301 and 306) Complife Support Line+39 0382 25 504Tests…
Acute Toxicity: Acute systemic toxicity testing concerns the assessment of the systemic toxic effects of a single dose or multiple doses of a product by a particular route (oral, dermal, inhalation). BALB 3T3 NRU cytotoxicity in vitro assay is useful to estimate starting doses for acute oral systemic toxicity tests. Officially accepted in vivo tests…
Cytotoxicity: Cytotoxicity tests are used to assess the biocompatibility (toxicity or irritancy potential) of a device or an extract with Balb/c 3T3 cells. The assay, performed according to EN ISO 10993-5 or USP 34, provides an excellent model to screen medical devices prior to in vivo tests. Complife Support Line+39 0382 25 504Tests & AnalysisEfficacy…
Skin Irritation and Corrosion: Topical exposure to chemicals can lead to adverse skin effects. Depending on the severity and reversibility of the response it is possible to distinguish between skin corrosion and irritation. Corrosive substances irreversibly damage the skin, while irritant substances lead to a reversible local inflammatory reaction. In vitro test methods, including assays…
Phototoxicity: Phototoxicity (photoirritation) is the toxic response of a cell model (Balb/c 3T3 cell line) to the test product when exposed to the light. The assay is carried out on products able to absorb the UV light or products that are applied under light exposure (i.e. day creams, sunscreens, etc.). The assay is performed according…
Percutaneous and Mucosal Absorption: Percutaneous absorption test measures the diffusion of chemicals into and across skin/epithelium to a fluid reservoir. Such methods are useful to monitor and compare the delivery of chemicals deriving from different formulations into and through skin layers, as well as are reliable models for the assessment of percutaneous absorption in humans.…
Ocular Irritation A number of OECD Test Guidelines based on in vitro methods related to the endpoint “Eye Irritation” is currently available or proximate to validation/update. A stepwise testing strategy is recommended for the assessment of the eye irritation/corrosion potential of cosmetic/household substances. Our testing services include: Organotypic in vitro assays: Bovine Corneal Opacity &…
Mucosal Tolerability: Mucosal tolerability test is useful to assess the tissue-specific irritation potential of the test product and is evaluated through different ex vivo (engineered tissues) models: Oral epithelium Gengival epithelium Vaginal epithelium Airway epithelium Intestinal epithelium Complife Support Line+39 0382 25 504Tests & AnalysisEfficacy TestsSafety TestsChemical AnalysisMicrobiological Tests Markets Cosmetics Medical Devices Nutrition Household…
Genotoxicity and Mutagenicity: The evaluation of genotoxicity and mutagenicity represents an important step in the safety assessment of products and is used for their classification and labelling. Our testing services include: Bacterial reverse mutation test (Ames test) – OECD 471 Micronucleus test and Comet assay Complife Support Line+39 0382 25 504Tests & AnalysisEfficacy TestsSafety TestsChemical…