Skin Hydration / Moisturization

Skin deep hydration/moisturization Efficacy: Skin deep hydration/moisturization is measured by means of corneometry. The instrument measures the skin water content of the deep skin layers based on the capacitance measurement. Claims Skin deep hydration Skin deep moisturization Other techniques Water holding capacity test Moisture accumulation test Trans-epidermal water loss Digital imaging (MoistureMap) Self-assessment (consumer test)…

Anti Wrinkle

Anti wrinkle efficacy is assessed using different techniques: Wrinkle surface, depth, volume, and others skin texture parameters are measured using a real 3D camera. Wrinkle analysis is integrated with the measurement of skin conditions (moisturization, elasticity, etc.) using bioengineering techniques. Instrumental measurements can be associated with experts scoring and dermatological assessment. Claims Anti wrinkle efficacy…

Genotoxicity and Mutagenicity

Genotoxicity and Mutagenicity: The evaluation of genotoxicity and mutagenicity represents an important step in the safety assessment of products and is used for their classification and labelling. Our testing services include: Bacterial reverse mutation test (Ames test) – OECD 471 Micronucleus test and Comet assay Complife Support Line+39 0382 25 504Tests & AnalysisEfficacy TestsSafety TestsChemical…

Coadjuvant in the treatment of acne

Anti acne efficacy is assessed using different techniques: Antimicrobial efficacy testing is a useful step to screen the efficacy of ingredients/products in counteracting the bacteria involved in the onset/development of acne. The inhibitory concentration of the ingredient/product on Propionibacterium acnes and Staphylococcus epidermidis growth is assessed through microbiological tests carried out according to international recognized…

Sun protection (SPF, UVAPF, WR)

Sun Protection¬†efficacy is assessed using different techniques: Sun Protection efficacy. Our testing services include UVA protection, Sun Protection Factor (SPF), and Water Resistance (WR) assessment according to the relevant methods compliant with European, American, Canadian, Australian, and Asian requirements. Sun protection test includes both in vitro and in vivo (on humans) methods. Claims UVA Protection…

Wound healing / Reparative efficacy

Wound healing / Reparative efficacy is assessed using different techniques: Morphological and histological analyses are conducted to evaluate the efficacy of a product in healing an artificial wound induced on cell monostrate or reconstructed tissues: Distance reduction of the wound edges are measured, while cell viability, protein metabolism and interleukin and cytokeratin panel are assessed…

Antinflammatory / Soothing efficacy

Antinflammatory / Soothing efficacy is assessed using different techniques: Inflammatory enzymes such as cyclooxygenase (COX) and lipoxygenase (LOX) are dosed through biochemical assays in order to assess the product efficacy to neutralize or sooth inflammatory stress conditions. Biological assays on cell cultures or reconstructed tissues are a valid alternative to monitor COX and LOX pathways,…

Protection from damage agents

Protection from damage agents efficacy is assessed using different techniques: Possible damage agents related to skin stress conditions are: Heavy metals / urban powder / synthetic smoke (environmental pollution); chemical irritating agents; biological inflammatory agents; photo-induced injuries (UV irradiation); oxidizing agents (oxidative stress). Biochemical kinetic and colorimetric assays are usually performed to quantify antioxidant enzyme…

Absorption / Penetration / Deposition efficacy

Absorption / Penetration / Deposition efficacy is assessed using different techniques: Absorption of a substance/product may be assessed after topical application on a biological matrix, measuring the amount of substance penetrating, absorbed and deposed on the meambrane. Used models includes synthetic membranes or biological matrices such as human reconstructed tissues (epidermis/full thickness skin/epithelia), human skin…