Complife is a worldwide group, which provides consulting and testing services for food, food supplements, household products, cosmetotextiles, cosmetics and pharma companies.

Determination of PAO

Determination of PAO Determination of PAO (Period After Openng) for a cosmetic product is a very difficult task, as, beside the varibility of the cosmetic formulation, it depends on several factors that are not easily framed, such as the product presentation (packaging and volume), the mode of using etc. Therefore COMPLIFE service for PAO evaluation…

Stability Studies

Stability of products: Chemical-physical stability microbiological stability ICH protocols lomg-term and accelerated shelf-life studies Complife Support Line+39 0382 25 504Tests & AnalysisEfficacy TestsSafety TestsChemical AnalysisMicrobiological Tests Markets Cosmetics Medical Devices Nutrition Get more info about this test Discover how your dedicated experts Dr. Maximilian Orlandi & Dr. Silvia Lancetti can support you CONTACT US

In-Use test

In-use test: Efficay of preservative systems in anhyodrous products can be evaluated through In-Use Test: samples are distributed to volunteers and used for a defined period, after that microbiological tests are carried out Complife Support Line+39 0382 25 504Tests & AnalysisEfficacy TestsSafety TestsChemical AnalysisMicrobiological Tests Markets Cosmetics Get more info about this test Discover how…

Challenge test

Challenge test: Efficacy of preservative system is to be used in the overall evaluation of the antimicrobial protection of a cosmetic product. The antimicrobial protection of a product can come from many sources: chemical preservation inherent characteristics of the formulation package design manufacturing process The evaluation of the preservation of a cosmetic formulation is based…

Reproductive toxicity

Reproductive toxicity: A set of in vitro testing for the reproduction risk assessment is performed, basing on assisted reproduction techniques, such as the in vitro oocyte maturation and fecundation assays on bovine model. In vitro maturation test: an assay reproducing the process of oocyte maturation, which corresponds to the pre-ovulatory in vivo phase that allows…

Ecotoxicity

Ecotoxicity: These assays are aimed at evaluating the environment risk hazard of substances, involving a number of different terrestrial and aquatic bioindicators (toxicity to algae Pseudokirchneriella subcapitata – OECD 201, crustacean Daphnia magna – OECD 202, fish Brachidanio rerio – OECD 203) and Biodegradability testing (OECD 301 and 306) Complife Support Line+39 0382 25 504Tests…

Acute Toxicity

Acute Toxicity: Acute systemic toxicity testing concerns the assessment of the systemic toxic effects of a single dose or multiple doses of a product by a particular route (oral, dermal, inhalation). BALB 3T3 NRU cytotoxicity in vitro assay is useful to estimate starting doses for acute oral systemic toxicity tests. Officially accepted in vivo tests…

Cytotoxicity

Cytotoxicity: Cytotoxicity tests are used to assess the biocompatibility (toxicity or irritancy potential) of a device or an extract with Balb/c 3T3 cells. The assay, performed according to EN ISO 10993-5 or USP 34, provides an excellent model to screen medical devices prior to in vivo tests. Complife Support Line+39 0382 25 504Tests & AnalysisEfficacy…

Sensitization

Sensitization¬†efficacy is assessed using different techniques: Sensitization tests are useful to assess whether the product in exam may cause adverse effects involving immunological mechanisms; in vitro methods are currently under validation process. The human Cell Line Activation Test (h-CLAT) quantifies the induction of protein markers on the surface of THP-1 cell lines after exposure to…

Skin Irritation and Corrosion

Skin Irritation and Corrosion: Topical exposure to chemicals can lead to adverse skin effects. Depending on the severity and reversibility of the response it is possible to distinguish between skin corrosion and irritation. Corrosive substances irreversibly damage the skin, while irritant substances lead to a reversible local inflammatory reaction. In vitro test methods, including assays…