Impurities content

Impurities content efficacy: “EU Cosmetic Regulation 1223/2009 specifically requires to evaluate the safety of cosmetic products by assessing the level of impurities: Cosmetic Allergens Heavy metals Acrylamide VOC (Volatile Organic Compounds) PHA (Policyclic Haromatic Compounds) Nitrosamine (NDELA) Formaldehyde ServicesAuditingCertificationConsultingInspectionTests and AnalysisChemical AnalysisEfficacy TestsMicrobiological TestsSafety TestsTraining Markets Cosmetics Medical Devices Nutrition Get more info about this…

Packaging compatibility

Packaging compatibility: Compatibility with the packaging is developed independently to stability to avoid confusion between problem of stability of the formula and problem caused by inadequate packaging. To assess the compatibility with the packaging, the cosmetic product is kept for a certain amount of time in controlled conditions, then specific characteristcs are evaluated, such as…

Determination of PAO

Determination of PAO Determination of PAO (Period After Openng) for a cosmetic product is a very difficult task, as, beside the varibility of the cosmetic formulation, it depends on several factors that are not easily framed, such as the product presentation (packaging and volume), the mode of using etc. Therefore COMPLIFE service for PAO evaluation…

Stability of products

Stability of products: Chemical-physical stability microbiological stability ICH protocols lomg-term and accelerated shelf-life studies ServicesAuditingCertificationConsultingInspectionTests and AnalysisChemical AnalysisEfficacy TestsMicrobiological TestsSafety TestsTraining Markets Cosmetics Medical Devices Nutrition Get more info about this testDiscover how your dedicated experts Dr. Maximilian Orlandi & Dr. Silvia Lancetti can support you Contact us

In-Use test

In-use test: Efficay of preservative systems in anhyodrous products can be evaluated through In-Use Test: samples are distributed to volunteers and used for a defined period, after that microbiological tests are carried out ServicesAuditingCertificationConsultingInspectionTests and AnalysisChemical AnalysisEfficacy TestsMicrobiological TestsSafety TestsTraining Markets Cosmetics Get more info about this testDiscover how your dedicated expert Dr. Roberta Vettorato…

Challenge test

Challenge test: Efficacy of preservative system is to be used in the overall evaluation of the antimicrobial protection of a cosmetic product. The antimicrobial protection of a product can come from many sources: chemical preservation inherent characteristics of the formulation package design manufacturing process The evaluation of the preservation of a cosmetic formulation is based…

Reproductive toxicity

Reproductive toxicity: A set of in vitro testing for the reproduction risk assessment is performed, basing on assisted reproduction techniques, such as the in vitro oocyte maturation and fecundation assays on bovine model. In vitro maturation test: an assay reproducing the process of oocyte maturation, which corresponds to the pre-ovulatory in vivo phase that allows…

Ecotoxicity

Ecotoxicity: These assays are aimed at evaluating the environment risk hazard of substances, involving a number of different terrestrial and aquatic bioindicators (toxicity to algae Pseudokirchneriella subcapitata – OECD 201, crustacean Daphnia magna – OECD 202, fish Brachidanio rerio – OECD 203) and Biodegradability testing (OECD 301 and 306) ServicesAuditingCertificationConsultingInspectionTests and AnalysisChemical AnalysisEfficacy TestsMicrobiological TestsSafety…

Acute Toxicity

Acute Toxicity: Acute systemic toxicity testing concerns the assessment of the systemic toxic effects of a single dose or multiple doses of a product by a particular route (oral, dermal, inhalation). BALB 3T3 NRU cytotoxicity in vitro assay is useful to estimate starting doses for acute oral systemic toxicity tests. Officially accepted in vivo tests…

Cytotoxicity

Cytotoxicity: Cytotoxicity tests are used to assess the biocompatibility (toxicity or irritancy potential) of a device or an extract with Balb/c 3T3 cells. The assay, performed according to EN ISO 10993-5 or USP 34, provides an excellent model to screen medical devices prior to in vivo tests. ServicesAuditingCertificationConsultingInspectionTests and AnalysisChemical AnalysisEfficacy TestsMicrobiological TestsSafety TestsTraining Markets…